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. 2016 Jul 8;6:28891. doi: 10.1038/srep28891

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Copyright © 2016, Macmillan Publishers Limited

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(A) Expression of keratinocyte markers and (B) melanocyte markers in transdifferentiated MT-MET-4 cells compared to MET-4 cells. Several keratinocyte markers were downregulated in the MT-MET-4 cells relative to the MET-4 cells. Error bars show SD of three independent experiments. P values were calculated by two-tailed, unpaired sample t-test (*p < 0.05, **p < 0.01, ***p < 0.005). (C) Western Blot analysis of the expression of the melanocyte markers MITF and DCT. (D) Electron microscope pictures showing stage I to IV of melanosomes in human melanocytes. Melanosomes in stage I-III were present in MT-MET-4 cells. Transdifferentiated HaCaT cells contained high amount of melanosomes from all four stages.