Table IV. Gene ontology (GO) enrichment terms for prefrontal cortex proteins with nominally significant downregulation in subgroup AD1 versus control subjects. No GO term was significantly enriched relative to the background of all assayed proteins for upregulated proteins in the comparison of AD1 versus control subjects, nor for up- and down-regulated proteins in the comparison of AD2 versus control subjects.

Term	Genes	Fold enrichment	P value	Benjamini
GO:0014069∼postsynaptic density	GRIN2B, GRIA2, GRIA4, SHANK3, GRIA3, HOMER1, GRM3, DLGAP2	6.90	5.63E-06	2.62E-04
GO:0045211∼postsynaptic membrane	GRIN2B, GRIA2, GRIA4, SHANK3, GRIA3, HOMER1, GRM3, DLGAP2	7.33	3.39E-06	3.15E-04
GO:0044456∼synapse part	GRIN2B, GRIA2, GRIA4, SHANK3, GRIA3, HOMER1, GRM2, GRM3, DLGAP2	4.55	2.56E-05	7.92E-04
GO:0044430∼cytoskeletal part	GRIN2B, GRIA2, GRIA4, SHANK3, GRIA3, HOMER1, GRM3, MAP2, DLGAP2	3.57	1.99E-04	0.0046
GO:0045202∼synapse	GRIN2B, GRIA2, GRIA4, SHANK3, GRIA3, HOMER1, GRM2, GRM3, DLGAP2	3.14	5.52E-04	0.010
GO:0030425∼dendrite	GRIN2B, GRIA4, GRIA3, GRM3, MAP2, DLGAP2	5.50	0.0011	0.016
GO:0005856∼cytoskeleton	GRIN2B, GRIA2, GRIA4, SHANK3, GRIA3, HOMER1, GRM3, MAP2, DLGAP2	2.75	0.0016	0.020
GO:0044463∼cell projection part	GRIN2B, GRIA4, GRIA3, GRM3, MAP2	6.67	0.0022	0.025
GO:0043005∼neuron projection	GRIN2B, GRIA4, GRIA3, GRM2, GRM3, MAP2, DLGAP2	3.54	0.0031	0.031
GO:0043228∼nonmembrane-bounded organelle	GRIN2B, GRIA2, GRIA4, SHANK3, GRIA3, HOMER1, GRM3, MAP2, DLGAP2	2.44	0.0038	0.035
GO:0043232∼intracellular nonmembrane-bounded organelle	GRIN2B, GRIA2, GRIA4, SHANK3, GRIA3, HOMER1, GRM3, MAP2, DLGAP2	2.44	0.0038	0.035
GO:0030054∼cell junction	GRIN2B, GRIA2, GRIA4, SHANK3, GRIA3, HOMER1, DLGAP2	3.31	0.0046	0.038