Table I. TFs and coregulators activated upon UHRF2 expression.
| TF families | Function | Pathway | Fold change (OE/control) | Biological roles involved ina | |
|---|---|---|---|---|---|
| TFAP2C | AP2 | Transcriptional activator and repressor | 9.74 | Activate genes in development; suppress MCAM/MUC18,C/EBP alpha and MYC; MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer | |
| EYA1 | TC | Transcriptional Coactivator; | 7.03 | DNA repair; organogenesis; embryonic development | |
| histone phosphatase | |||||
| ZNF451 | ZNF | Coactivator for steroid receptors | 6.18 | ||
| DLX1 | Homeobox | Transcriptional regulator | TGFβ–SMAD2/3 | 5.00 | Development of the ventral forebrain |
| RUNX1 | p53 | 4.74 | Binds to the core element of many enhancers and promoters; development of normal hematopoiesis; leukemia | ||
| CHD7 | Probable transcription regulator | 4.22 | Maybe involved in the in 45S precursor rRNA production | ||
| TCF12 | bHLH | Transcriptional regulator; EMT-TF | ERK | 3.70 | Initiation of neuronal differentiation; activates transcription by binding to the E box (5-CANNTG-3) |
| WWTR1 | TC | Transcriptional coactivator | Hippo | 3.70 | downstream regulatory target in the Hippo; organ size control and tumor suppression |
| DEAF1 | SAND | Transcriptional regulator | 3.30 | Embryonic development; inhibitor of cell proliferation; expression of peripheral tissue antigens in pancreatic lymph nodes | |
| CDCA7L | TC | transcriptional repressor | 3.05 | Oncogenic role; downstream of P38-kinase and BCL-2; upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 | |
| TWIST2 | bHLH | EMT-TF | MAPK | 2.89 | Cancers; metastsis |
| DBP | bZIP | Transcriptional activator | 2.65 | Circadian rhythm generation | |
| ACTR5 | TC | 2.60 | Proposed core component of INO80 complex; DNA replication and probably DNA repair; double-strand break repair and UV-damage excision repair | ||
| HNF1B | Homeobox | Transcriptional regulator | 2.43 | Nephron development; development of the embryonic pancreas diabetes; cancer | |
| HELLS | TC | 2.16 | Normal development and survival; regulation of the expansion or survival of lymphoid cells; de novo or maintenance DNA methylation; formation and organization of heterochromatin; regulation of transcription and mitosis | ||
| MXD4 | bHLH | Transcriptional repressor | 2.10 | A member of the MAD gene family; tumor suppressors; regulation of cell growth | |
| NFE2L2 | bZIP | Transcription activator | 2.08 | Regulates genes which contain ARE in promoters; response to oxidative stress | |
| TCF3 | bHLH | Transcriptional regulator; EMT-TF | Wnt | 1.93 | Lymphopoiesis; ymphoid malignancies; tumor metastasis |
| TFEB | bHLH | Transcriptional coactivator | Wnt | 1.85 | Humoral immunity; expression of lysosomal genes; autophagy; migratory phenotype; cancer |
| FOXC2 | Forkhead | Transcriptional activator; EMT-TF | TGFβ–SMAD3 | 1.83 | Formation of special mesenchymal tissues |
| ZMYND11 | TC | Transcriptional corepressor | 1.78 | Chromatin reader that specifically recognizes and binds H3.3K36me3 and regulates RNA polymerase II elongation; acts as a tumor-suppressor | |
| SATB2 | Homeobox | Transcriptional regulator | 1.72 | Chromatin remodeling | |
| TCF7L2 | HMG | Repressor in the absence of CTNNB1, activator in its presence; EMT-TF | Wnt | 1.72 | Blood glucose homeostasis; diabetes; tumor metastasis |
| ZMYND8 | TC | Transcriptional corepressor | 1.67 | Receptor for activated C-kinase (RACK) protein | |
| TRRAP | TC | Epigenetic transcription activation | Wnt | 1.56 | Component of many histone acetyltransferase (HAT) complexes; transcription and DNA repair; p53/TP53-, E2F1- and E2F4-mediated transcription activation |
a Reference from GeneCards human gene database.