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. 2016 May 2;15(7):2324–2337. doi: 10.1074/mcp.M115.057661

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 2. — Heat map of quantitative analysis of sero-reactivity to 11 known citrullinated auto-antigens and Epstein-Barr Nuclear Antigen (EBNA) on contra captured protein arrays. Thirty serum samples (12 CCP+ RA patients, 8 CCP- RA patients, 10 healthy controls) were used for this study. The left half of the heat map shows sero-reactivity to native protein arrays and the right half shows sero-reactivity to citrullinated protein arrays. EBNA was used as a positive sero-profiling control because most adults show sero-positivity to this antigen. Blue, low reactivity; red, high reactivity.