Fig. 11.

Systems Biology analysis identifying further interactome and interplay among the top 12 new SCI biomarkers with additional CNS injury biomarkers αII-spectrin (SPTAN1; SPAN2(mouse)), UCHL1 and MBP, GFAP, and S100b. Systems Biology analysis was based on STRING program (http://string-db.org/) with action views using three species: human (A), mouse (B), and rat (C). Blue lines indicate interactions, arrows indicate regulations, whereas gray lines identify possible associations. Green circles identified key interaction clusters identified.