Quantification of biomarker release human CSF after SCI. (A) Biomarker levels at initial time point (First sample taken- usually within 36 postinjury) and all time points (all samples from day 0 to 6 post-SCI). Transferrin (signals × ¼ is shown), CathD, TPI-1, and PEA-15 (signals × 25 is shown). (* p < 0.05, **, p < 0.001, as compared with control CSF, unpaired t test). B, Time course of biomarker levels in CSF for all patients (n = 14). Mean + S.E. are shown. Trend lines shown are moving averages of biomarker levels from two adjacent time points.