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. 2016 Apr 19;15(7):2435–2447. doi: 10.1074/mcp.M115.056366

Table II. Cell wall proteins and functions. In bold are proteins with significantly increased levels in mutant strains compared to the wild-type strain. * At least twofold difference compared to the wild-type strain, p < 0.05.

Protein Mutants affected* Description
Gas1 5 Glycosylphosphatidylinositol (GPI)-anchored beta-1,3-glucanosyltransferase; required for cell wall assembly
Plb1 4 Phospholipase B (lysophospholipase) involved in lipid metabolism
Plb2 4 Phospholipase B (lysophospholipase) involved in lipid metabolism
Scw4 4 Cell wall protein with similarity to glucanases; paralog is SCW10
Uth1 3 Probable secreted beta-glucosidase; implicated in cell wall biogenesis, paralog is NCA3
Bgl2 2 Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall
Exg2 2 Exo-1,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be a (GPI) anchored protein
Mkc7 2 GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; paralog is YPS1
Tos1 2 Covalently-bound cell wall protein of unknown function; has sequence similarity to TOH1
Toh1/Yjr1 2 Also known as: JL171C, P46992. GPI-anchored cell wall protein; unknown function; sequence similarity to TOS1.
Yps1 1 GPI-anchored aspartic protease; hyperglycosylated member of the yapsin family of proteases
Pst1 1 Cell wall protein that contains a putative GPI-attachment site; up-regulated by activation of the cell integrity pathway, paralog is ECM33
Bar1 0 Aspartyl protease; secreted into the periplasmic space of mating type a cell
Ccw14 0 Covalently linked cell wall glycoprotein; present in the inner layer of the cell wall
Cis3 0 Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
Crh1 0 Chitin transglycosylase; functions in the transfer of chitin to beta(1–6) and beta(1–3) glucans in the cell wall; similar and functionally redundant to Utr2; expression induced by cell wall stress
Crh2 0 Chitin transglycosylase; functions in the transfer of chitin to beta(1–6) and beta(1–3) glucans in the cell wall; similar to and functionally redundant with Crh1; GPI-anchored protein localized to bud neck
Cwp1 0 Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond
Ecm33 0 Paralog is PTS1
Gas3 0 Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI-containing proteins
Gas5 0 1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall
Hsp150 0 O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; paralog is PIR3
Pir1 0 O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; expression regulated by the cell integrity pathway; paralog is YJL160C
Pry3 0 Cell wall-associated protein involved in export of acetylated sterols
Scw10 0 Paralog is SCW4
Yps7 0 Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance