Table 4.

Regression models for outcome variables a) palliative care concerns (total MyPOS score), b) global quality of life (EORTCQLQ-C30 subscale), and c) generic health-related quality of life (EQ5D Index score) and their association with demographic, clinical characteristics and symptom burden (n = 557)

	Palliative care concerns			Global quality of life QLQ-C30			EQ5D Index
Independent variables	Coefficient	Lower CI	Upper CI	Coefficient	Lower CI	Upper CI	Coefficient	Lower CI	Upper CI
(Constant)	20.639**	14.189	27.089	105.788**	100.986	110.589	1.168**	1.093	1.242
General symptom level	1.439**	1.136	1.741	–	–	–	–	–	–
Pain	0.046*	0.016	0.076	−2.572*	−4.168	−0.975	−0.100**	−0.129	−0.071
Weakness/lack of energy	–	–	–	−5.741**	−7.395	−4.086	–	–	–
Drowsiness	–	–	–	–	–	–	0.032	0.000	0.064
Dry mouth	1.395**	0.558	2.233	–	–	–	–	–	–
HADS Anxiety	1.100**	0.891	1.308	−2.519*	−4.091	−0.947	–	–	–
HADS Depression	–	–	–	−3.749**	−5.446	−2.052	−0.075**	−0.102	−0.048
Age	−0.136**	−0.204	−0.069	–	–	–	–	–	–
Being in the stable/plateau phasea	−2.693**	−4.096	−1.290	4.804**	2.127	7.482	–	–	–
ECOG performance status 2b	–	–	–	−3.654	−7.449	0.141	–	–	–
ECOG performance status 3/4 – limited self-care or completely disabledc	–	–	–	–	–	–	−0.159**	−0.248	−0.070
Physical function/Poor mobility	−0.138**	−0.174	−0.101	−5.085**	−6.610	−3.560	−0.082**	−0.110	−0.054
Adjusted R2	0.879			0.514			0.584
F, P	F = 192.205	P < 0.001		F = 85.522	P < 0.001		F = 61.924	P < 0.001

ECOG Eastern Cooperative Oncology Group performance status, CI confidence interval, EQ5D EuroQol-5D-3L, HADS Hospital Anxiety and Depression Scale, MyPOS Myeloma Patient Outcome Scale

^aReference group is patients being unstable, i.e. newly diagnosed or having relapsed, progressive or palliative disease or being in a treatment-interval

^bReference group is ECOG performance status of 0

^cReference group is ECOG performance status of 0

*p < 0.05

**p < 0.001