Table 2.

Comparison of Clostridium difficile infected patients’ presentations between those who were treated with adjunctive intracolonic vancomycin and those who received therapy without intracolonic vancomycin

	Therapy with adjunctive intracolonic vancomycin No. (%) or average ± s.d.	Therapy without intracolonic vancomycin No. (%) or average ± s.d.	P value*
Total Number	26 (20.5 %)	101 (79.5 %)
Severe Disease	7 (26.9 %)	12 (11.9 %)	0.11
Moderate Disease	19 (73.1 %)	89 (88.1 %)	0.70
Age (years + SD)	67 ± 8	70 ± 13	0.31
Male Sex	25 (96.2 %)	82 (81.2 %)	0.07
Average Severity Score Index for Total Group	5.69 ± 1.4	5.02 ± 1.0	0.03
Severe Disease	7.58 ± 0.98	7.08 ± 0.29	0.24
Moderate Disease	5.00 + 0.75	4.74 + 0.75	0.17
Past Medical History
Recent surgery within last 6 weeks	9 (34.6 %)	25 (24.7 %)	0.31
History of CDI within the past 12 months	7 (26.9 %)	11 (10.9 %)	0.06
Comorbidities
Diabetes mellitus	13 (50.0 %)	34 (33.7 %)	0.12
Coronary artery disease	9 (34.7 %)	26 (25.7 %)	0.37
Congestive heart failure	7 (15.4 %)	18 (17.8 %)	0.30
COPD	9 (34.6 %)	25 (24.8 %)	0.31
Malignancy	8 (20.7 %)	30 (29.7 %)	0.92
Cirrhosis	1 (3.8 %)	5 (5.0 %)	1.00
Admission Medications
Proton pump inhibitors	13 (68.4 %)	62 (57.4 %)	0.45
Aspirin	8 (42.1 %)	36 (34.0 %)	0.46
H2 blockers	4 (21.1 %)	35 (32.4 %)	0.42
Corticosteroids	3 (15.8 %)	33 (30.1 %)	0.27
Laboratory Values within the first 72 h of the diagnosis of CDI
WBC (cells/mm3)	27.2 ± 14.9	24.1 ± 16.9	0.36
Hgb (g/L)	10.1 + 1.9	10.0 ± 3.1	0.84
Albumin (g/dL)	1.7 ± 0.5	1.8 ± 0.5	0.55
BUN (mg/dL)	46.4 ± 28.2	42.3 ± 33.0	0.51
Creatinine (mg/dL)	2.2 ± 1.8	2.2 ± 1.8	0.97
Prior antibiotics within 8 weeks of diagnosis of CDI	24 (92.3 %)	94 (93.1 %)	0.76

*Because of multiple hypotheses testing, a p value ≤ 0.01 determined statistical significance

SD standard deviation, CDI Clostridium difficile infection, COPD chronic obstructive pulmonary disease, WBC white blood cell, Hg hemoglobin, BUN blood urea nitrogen