Table 2.
Baseline variables for both severe and non-severe acidosis
| ACPE N = 240 |
COPD N = 540 |
OHS N = 189 |
All N = 969 |
|||||
|---|---|---|---|---|---|---|---|---|
| pH Patients |
≤7.25 109 |
>7.25 131 |
≤7.25 219 |
>7.25 322 |
≤7.25 72 |
>7.25 117 |
≤7.25 399 |
>7.25 570 |
| Age, years, X (SD) | 76 (10) | 75 (10) | 71 (9) | 70 (9) | 72 (10) | 70 (11) | 73 (10) | 71 (10)** |
| Sex, male, % | 40 | 44 | 88 | 86 | 49 | 29** | 61 | 46*** |
| BMI, X (SD) | 33 (7) | 30 (8)* | 26 (5) | 29 (6)*** | 37 (8) | 40 (8)** | 30 (7) | 32 (8)** |
| Smoker, % | 6.3 | 4.8 | 16 | 36*** | 11 | 19 | 12 | 23** |
| Drinker, % | 3.2 | 6.5 | 6 | 12* | 9 | 9 | 5 | 9* |
| Respiratory rate, X (SD) | 25.4 (6.6) | 25.3 (4.5) | 25.8 (3.9) | 25.6 (5.1) | 24.6 (3.7) | 23.5 (4.1)* | 25.5 (3.8) | 25.1 (4.8)* |
| Systolic BP, mmHg, X (SD) | 133 (24) | 135 (19) | 133 (20) | 134 (21) | 143 (20) | 129 (17)*** | 135 (21.1) | 133.3 (19.8) |
| Diastolic BP, mmHg, X (SD) | 72 (17) | 73 (14) | 72 (10) | 74 (12)* | 76 (10) | 69 (11)*** | 72.6 (12.2) | 72.5 (12.5) |
| Charlson index, X (SD) | 3.2 (1.3) | 2.5 (1)*** | 2.2 (1.2) | 2.3 (1.1) | 2.2 (1.5) | 1.9 (0.9) | 2.5 (1.4) | 2.3 (1.1)* |
| Glasgow scale, X (SD) | 13.4 (1.6) | 13.7 (1.9)*** | 13.7 (1.1) | 14 (1.1)*** | 13.5 (1.9) | 14 (1.3)** | 13.6 (1.4) | 14 (1.4)*** |
| APACHE II score, X (SD) | 20.7 (7.2) | 19.1 (5.8)* | 19.7 (5.7) | 18.7 (5.1)** | 18.3 (5.9) | 17.4 (4.7) | 19.7 (6.2) | 18.5 (5.2)** |
| PaO2, mmHg, X (SD) | 70 (28) | 65 (32)* | 64 (35) | 61 (22) | 59 (17) | 59 (24) | 65 (31) | 61 (25) |
| PaO2/FiO2, X (SD) | 178 (82) | 191 (97) | 180 (103) | 198 (76)*** | 164 (62) | 186 (80)* | 176 (92) | 194 (82)*** |
| PaCO2, mmHg, X (SD) | 87 (22) | 70 (15)*** | 87 (21) | 76 (14)*** | 83 (17) | 74 (14)** | 86 (21) | 75 (14)*** |
| PH, X (SD) | 7.18 (0.07) | 7.30 (0.03)*** | 7.19 (0.05) | 7.30 (0.25)*** | 7.19 (0.05) | 7.30 (0.03)*** | 7.18 (0.06) | 7.30 (0.03)*** |
| FVC, %, X (SD) | 60 (10) | 62 (12)* | ||||||
| FEV1, %, X (SD) | 36 (9) | 41 (10)*** | ||||||
| RICU type 1, % | 78 | 57** | 62 | 59 | 58 | 43 | 66 | 55** |
| PS mode, % | 67 | 69 | 72 | 88* | 50 | 69* | 68 | 81** |
| CPAP/NIV, % | 11 | 22 | 17 | 24 | 38 | 27 | 19 | 24 |
| DNI order, % | 66 | 64 | 75 | 59*** | 56 | 53 | 68 | 59** |
Abbreviations: X (SD) mean (standard deviation), BMI body mass index, BP blood pressure, RICU respiratory intermediate care unit, PS pressure support, CPAP/NIV previous continuous positive airway pressure or noninvasive ventilation, DNI do not intubate
* P < 0.05, ** P < 0.01, and *** P < 0.001