Table 3.
Baseline demographic and clinical data following G6PD genotypes
| Characteristic | Male normal (n = 114) | Male hemizygous (n = 32) | Female normal (n = 88) | Female heterozygous (n = 40) | Female homozygous (n = 4) | All children (n = 278) |
|---|---|---|---|---|---|---|
| Age, years [range] | 3.3 (2.8) [0–10] | 2.6 (2.2) [0–8] | 2.2 (1.9) [0–8] | 2.3 (2.6) [0–10] | 2.5 (3) [0–6] | 2.7 (2.5) [0–10] |
| 0–3, n (%) | 65 (57) | 23 (72) | 69 (78) | 30 (75) | 2 (50) | 189 (68) |
| 4–7, n (%) | 39 (34) | 8 (25) | 18 (21) | 7 (18) | 2 (50) | 74 (27) |
| ≥8, n (%) | 10 (9) | 1 (3) | 1 (1) | 3 (7) | 0 (0) | 15 (5) |
| Weight, kg | 15.6 (5.2) | 12.6 (4.7) | 13.2 (4) | 13.2 (5.9) | 16.3 (2.7) | 14.1 (5) |
| Parasitemia per μL, geometric mean [range] | 150,464 [6240–1,270,080] | 95,369 [8153–709,400] | 138,296 [5377–1,677,780] | 105,520 [6380–745,100] | 172,340 [32,176–397,440] | 132,349 [5377–1,677,780] |
| Temperature, °C | 37.9 (1.1) | 38.4 (1) | 38.2 (1.1) | 38 (1.2) | 37.7 (1.3) | 38.1 (1.1) |
| Haemoglobin, g/dL (years) | 8.9 (2.4) | 7.8 (2.3) | 8.9 (2.3) | 7.1 (2.3) | 8.2 (1.4) | 8.5 (2.4) |
| 0–3 | 8.2 (2.4) | 7.6 (2.1) | 8.6 (2.3) | 6.7 (2.2) | 8.1 (2.1) | 8.1 (2.4) |
| 4–7 | 9.9 (2) | 8.2 (2.8) | 9.7 (1.8) | 6.9 (2) | 8.3 (1.3) | 9.3 (2.2) |
| ≥8 | 9.8 (1.8) | NA | NA | 10.6 (0.6) | NA | 10.2 (1.7) |
| Haematocrit, % | 27.4 (7.3) | 23.8 (7.1) | 27.3 (7) | 21.7 (7.6) | 25.5 (4) | 26.1 (7.5) |
| Red blood cell count, 10^12/L | 3.8 (1) | 3.3 (1.2) | 3.6 (1) | 3 (1) | 3.1 (0.4) | 3.6 (1.1) |
| Platelet count, 10^9/L | 151.6 (230.4) | 98 (82) | 117.3 (118.8) | 111 (77.7) | 63.3 (30) | 127.5 (167.9) |
| White blood cell count, 10^9/L | 9.4 (4.2) | 11.6 (7.9) | 9.8 (4.3) | 11.6 (4.4) | 7.7 (3.4) | 10.1 (4.9) |
Values are mean (SD) [range] unless otherwise indicated. G6PD genotype: male normal = A or B; male hemizygous = A−; female normal = B/B or B/A or A/A; female homozygous = A−/A−; female heterozygous = B/A− or A/A−
NA not applicable; SD standard deviation