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Conversion of 4-aminopyridine to 3-hydroxy-4-aminopyridine after incubation with recombinant human CYP enzymes. (A) 4-aminopyridine concentration 10 μM. (B) 4-aminopyridine concentration 100 μM. Values are blank-corrected with respect to controls. NC, not calculated since no value was detected, values were below the lowest standard, or were less than zero after blank correction; ND, not determined (samples were incorrectly prepared).
