Table 1.
Markers and inhibitors of human microsome enzyme activities.
| Enzyme | Marker activity | Inhibitor (solvent) |
|---|---|---|
| 1A2 | Phenacetin O-dealkylation | α-Naphthoflavone (acetonitrile 0.5%) and furafylline* (water) |
| 2A6 | Coumarin 7-hydroxylation | 8-Methoxypsoralen* (water) |
| 2B6 | Bupropion hydroxylation | Phencyclidine* (water) and thio-TEPA* (water) |
| 2C8 | Paclitaxel 6α-hydroxylation | Montelukast (acetonitrile 0.5%) |
| 2C9 | Diclofenac 4′-hydroxylation | Sulfaphenazole (acetonitrile 0.5%) |
| 2C19 | S-Mephenytoin 4′-hydroxylation | Ticlopidine* (water) |
| 2D6 | Dextromethorphan O-demethylation | Quinidine (water) |
| 2E1 | Chlorzoxazone 6-hydroxylation | Diethyldithiocarbamate* (water) |
| 3A4/5 | Testosterone 6β-hydroxylation | Ketoconazole (acetonitrile 0.5%) and troleandomycin* (acetonitrile 0.5%) |
| 3A4/5 | Midazolam 1′-hydroxylation | Ketoconazole (acetonitrile 0.5%) and troleandomycin* (acetonitrile 0.5%) |
| 4A11 | Lauric acid 12-hydroxylation | 10-Imidazolyl-decanoic acid (water) |
| FMO3 | Benzydamine N-oxidation | – |
*Time-dependent inhibitor