Table 3.

Predictors of improvement in CAT total score (at least two points) from baseline to week 12 (multivariate logistic regression)

	CAT total score improvement (at least two points)
	OR (95% CI)	p
CAT baseline scorea	1.10 (1.08; 1.13)	<0.01
Women	1.26 (0.95; 1.69)	0.11
Men	(ref.)
Age (years)	1.00 (0.98; 1.02)	0.87
Current smoker (baseline)	0.87 (0.63; −1.20)	0.41
Not current smoker (baseline)	(ref.)
BMI (baseline)
Underweight	1.39 (0.72; 2.74)	0.54
Normal	(ref.)
Overweight or obese	1.12 (0.83; 1.52)
FEV1 ≥50% (baseline)	1.57 (1.14; 2.16)	0.01
FEV1 <50% (baseline)	(ref.)
CV co-morbidityb (baseline)	0.83 (0.57; 1.23)	0.36
No CV co-morbidity (baseline)	(ref.)
Prior medication (baseline)
LAMA naive without maintenance	1.84 (1.26; 2.71)	<0.01
LAMA naive with maintenance	1.95 (1.30; 2.95)
LAMA non-naive without maintenance	1.19 (0.75; 1.91)
LAMA non-naive with maintenance	(ref.)

^aCOPD assessment test measured at baseline visit.

^bCV comorbidity = heart failure or ischemic disease.