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. 2016 Apr 16;9(3):220–226. doi: 10.1016/j.jiph.2016.04.002

Figure 3.

Figure 3

Non-obligate chain termination of hepatitis C through RNA-dependent, template-directed RNA synthesis by incubation with BCX4430 triphosphate (BCX6870) in vitro. Chain termination as a result of incorporation of BCX4430 is shown in lanes 5 and 8. Lanes 4 and 7 show 3′-deoxyATP, a known obligate chain terminator positive control. Lane 6 shows the pattern of RNA oligomers made with no inhibitors present or normal nucleotides present.

Reproduced from [5].