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Variation in and low efficiency of conversion of BCX4430 to BCX4430-TP in cell lines commonly used for in vitro evaluation of antiviral activity of test agents; the data shown indicate mean and SD. Redrawn from [5]; right-hand scale indicates the percent of BCX4430-TP mean levels observed at 24 h in fresh human hepatocytes. The cell lines were incubated with 10 μM BCX4430 for the indicated times, and the levels of BCX4430-TP were quantitated by HPLC.
