Figure 15.

Gene expression analysis comparing the LD ALL3 in presence and absence of HDSN. (A) Venn-diagram showing up-regulated genes on days 1, 3, and 6. There are 50 genes up-regulated commonly in LDH comparing LD at day1, 3, and 6. Here, LD= LD ALL3 cells (non-stimulated cells) and LDH= LD+HDSN (stimulated cells). (B) Venn-diagram showing down-regulated genes on days 1, 3, and 6. There are 42 genes down-regulated commonly in LDH comparing LD at days 1, 3, and 6. The visualization for the bar graphs (C-F) have benn made according to combined score (Combined score= p-value computed using the Fisher exact test, and the z-score computed to assess the deviation from the expected rank). The length of the bar represents the significance of that specific gene-set or term. In addition, the brighter the color, the more significant that term is (adapted from and refer to [63] for more details).(C and D) show Gene ontology (GO) biological process and cellular component analsis of differentially expressed common 92 genes using EnrichR. (E and F) show KEGG and and WiKi pathway analysis of differentially expressed common 92 genes using EnrichR.