Table 1.
List of some of the common genes with significantly differential expression in HDSN stimulated LD ALL3 cells (LDH) compared to non-stimulated LD ALL3 (LD) cells
| Gene Symbol | Fold Change (LDH Vs LD) | ||
|---|---|---|---|
|
|
|||
| Day 1 | Day 3 | Day 6 | |
| Cholesterol, lipid, steroid, triglyceride metabolism and biosynthesis pathways | |||
| ABCG1 | 27.8 | 49.3 | 57.7 |
| ABCA1 | 9.2 | 18.5 | 21.1 |
| MYLIP | 8.8 | 7.8 | 10.9 |
| SREBF1 | 8.7 | 8.4 | 12.1 |
| INSIG1 | 8.3 | 2.5 | 4.0 |
| SCD | 8.1 | 3.6 | 4.3 |
| LDLR | 5.6 | 2.6 | 3.4 |
| SNTB1 | 4.8 | 2.2 | 2.6 |
| FASN | 3.3 | 3.0 | 2.2 |
| PIP5K1B | 3.1 | 2.3 | 2.8 |
| IGF1R | 3.0 | 3.5 | 4.6 |
| FADS1 | 2.9 | 2.1 | 2.0 |
| TCF7L2 | 2.3 | 4.7 | 4.0 |
| ELOVL2 | 2.2 | 2.1 | 3.8 |
| VLDLR | -2.1 | -2.5 | -4.3 |
| B cell proliferation/Signaling pathways | |||
| FAM129C | 27.4 | 49.2 | 121.2 |
| IFITM1 | 10.7 | 26.4 | 26.4 |
| CD22 | 4.1 | 2.7 | 4.1 |
| CD48 | 3.4 | 3.0 | 2.4 |
| NFATC1 | 2.7 | 2.2 | 2.2 |
| CD40 | 2.6 | 5.1 | 3.3 |
| TCF3 | 2.3 | 2.2 | 3.6 |
| HLA-E | 2.3 | 2.1 | 2.9 |
| BLNK | -2.7 | -2.2 | -2.4 |
| MEF2C | -2.9 | -2.3 | -3.2 |
| CDKN1A | -3.4 | -4.1 | -4.4 |
| PRDM1 | -4.1 | -3.4 | -7.5 |
| MS4A1 | -5.5 | -4.4 | -4.3 |
| CD1C | -6.4 | -3.1 | -8.2 |
| Cell cycle regulation/G1 to S cell cycle control | |||
| CTGF | 4.7 | 4.4 | 7.2 |
| TCF3 | 2.3 | 2.2 | 3.6 |
| PLCB1 | -2.5 | -3.5 | -2.4 |
| CDKN1A | -3.4 | -4.1 | -4.4 |
| CCPG1 | -3.6 | -7.9 | -5.8 |
| CCNA1 | -4.5 | -4.7 | -8.5 |
| Apoptosis | |||
| FAIM3 | 20.9 | 14.2 | 6.9 |
| BACH2 | 10.1 | 9.1 | 17.8 |
| TNFRSF19 | -3.7 | -4.5 | -4.4 |
| HMOX1 | -14.4 | -6.7 | -19.4 |
| Cell Secretion | |||
| CTGF | 4.7 | 4.4 | 7.2 |
| RAB27A | 3.2 | 2.6 | 4.1 |
| SRGN | -2.0 | -3.9 | -5.5 |
| LAMP2 | -2.7 | -3.0 | -3.8 |
| Transporter activity | |||
| SLC25A23 | 2.0 | 2.4 | 2.2 |
| VLDLR | -2.1 | -2.5 | -4.3 |
| SLC35B1 | -2.5 | -2.1 | -2.0 |
| SLC16A6 | -5.4 | -4.9 | -10.0 |
| SLC7A11 | -8.0 | -7.6 | -9.3 |
| Other Cancer related genes | |||
| ADARB1 | 10.0 | 5.2 | 12.8 |
| CHI3L2 | 7.6 | 5.3 | 14.0 |
| FAM69B | 7.5 | 6.3 | 10.2 |
| GPR18 | 4.8 | 5.4 | 4.3 |
| MAML3 | 4.6 | 7.1 | 15.2 |
| VWA5A | -1.1 | -5.4 | -10.3 |
| DOCK4 | -4.7 | -3.2 | -6.8 |
| SAMD9L | -5.1 | -4.3 | -3.4 |
| CHST2 | -5.6 | -2.5 | -10.7 |
| FTH1 | -7.4 | -3.7 | -8.6 |
| EGR3 | -9.3 | -3.4 | -6.9 |
| THSD7A | -12.1 | -5.0 | -9.0 |
| LOC284801 | -4.8 | -5.7 | -37.4 |
| CHST2 | -5.6 | -2.5 | -10.7 |
| MPEG1 | -5.8 | -6.3 | -11.2 |
The fold change is linear and positive values mean genes more expressed in LDH and negative values vice versa. In the case of single genes where more than one set of probes is significantly differentially expressed, the highest value amongst them is shown.