Figure 6.

CASZ1 promotes the epithelial-mesenchymal transition and cancer metastasis in EOC cells. Changes in the expression of EMT-associated genes in (A) CASZ1a- or CASZ1b-overexpressing TOV21G and A2780^CP70 cells and in (B) CASZ1-knockdown MCAS and RMUG cells were analyzed using immunoblotting assays. Epithelial marker: E-cadherin; mesenchymal markers: N-cadherin and α-smooth muscle actin (α-SMA). β-actin was used as the internal control. (C) The 5 most highly enriched networks identified by the MetaCore-based analysis of the microarray data derived from MCAS cells expressing sh-luc, sh-CASZ1 (2), and sh-CASZ1 (3).