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. Author manuscript; available in PMC: 2016 Nov 19.
Published in final edited form as: Cell. 2015 Nov 19;163(5):1176–1190. doi: 10.1016/j.cell.2015.10.062

Figure 4. Dopamine-induced [Ca2+]i mobilization correlates with formation of GHSR1a:DRD1 heteromers.

Figure 4

(A) Dopamine-induced [Ca2+]i mobilization measured in HEK-AEQ cells expressing DRD1 with either GHSR1a (■) or GHSR1a-Hom (▲) preincubated with increasing concentrations of homodimerization inducer (B/B).

(B and C) Dose-dependent dopamine-induced [Ca2+]i release in the absence (■) or presence (▲) of B/B in cells coexpressing GHSR1a-Hom and DRD1 (B) or in cells coexpressing GHSR1a and DRD1 (C).

Data represent the mean ± SEM of at least three independent experiments (*, p<0.05 versus control; **, p<0.01 versus control; ***, p<0.001 versus control).