(A) Dopamine-induced [Ca2+]i mobilization measured in HEK-AEQ cells expressing DRD1 with either GHSR1a (■) or GHSR1a-Hom (▲) preincubated with increasing concentrations of homodimerization inducer (B/B).
(B and C) Dose-dependent dopamine-induced [Ca2+]i release in the absence (■) or presence (▲) of B/B in cells coexpressing GHSR1a-Hom and DRD1 (B) or in cells coexpressing GHSR1a and DRD1 (C).
Data represent the mean ± SEM of at least three independent experiments (*, p<0.05 versus control; **, p<0.01 versus control; ***, p<0.001 versus control).