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The absolute value of the normalized bias of the ML, LR, and ADC-map estimation techniques for various amounts of heterogeneity in a heterogeneous lesion with uniform distribution of ADC values. The variation in heterogeneity is quantified by the range of the ADC values in this lesion. The experiment was performed for SNRb0 values equal to (a) 4, (b) 8, and (c) 12. The error bars denote 95% confidence intervals.
