TABLE I.

Absolute value of the average normalized bias (averaged over the parameter that is varied and the noise realizations) of the ADC values estimated using the LR, ADC-map, and proposed ML estimation methods. The bias is expressed in percentage units.

Type of lesion	Parameter varied	ML	LR	ADC-map
Homogeneous	ADC and SNR	4.63	10.55	16.00
	Size	3.33	6.66	5.82
Heterogeneous
-uniformly distributed	SNR	2.98	6.22	5.36
	Size	3.33	7.27	4.81
Heterogeneous
-rim model	SNR	3.00	6.29	4.83
	Size	3.19	7.23	4.78
Heterogeneous
-variegated lesion model	SNR	6.53	12.31	9.31
	Size	5.06	7.69	9.63