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. 2016 Feb 19;124(7):991–999. doi: 10.1289/ehp.1510006

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Effects of p,p′‑DDE, o,p′‑DDT, and bisphenol A (BPA) on follicle stimulating hormone (FSH)-stimulated cAMP production. Chinese hamster ovary–follitropin receptor (CHO-FSHR) cells were stimulated with 3 × 10^–2 IU/mL human FSH (hFSH) (left) and 3 IU/mL hFSH (right) in the presence of increasing doses of p,p′‑DDE (A), o,p′‑DDT (B), or BPA (C) (means ± SEM of three independent experiments performed in triplicate). The response to hFSH alone was arbitrarily set at 1. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 for the response in p,p′‑DDE, o,p′‑DDT, or BPA-exposed compared with unexposed cells, Mann-Whitney U test.