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. 2016 Feb 5;124(7):1071–1083. doi: 10.1289/ehp.1510194

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TCDD-mediated induction of cytokines and COX-2 in AhRR Tg and C57BL/6J wt mice. Expression of IL-1β, IL-6, IL-10, IL-22, TNFα, and COX-2 in liver, lung, kidney, adipose, spleen, and thymus of C57BL/6 mice wt and AhRR Tg male mice in response to TCDD. Male C57BL/6 wt and AhRR Tg mice were injected i.p. with a single dose of 20 μg/kg TCDD. Control animals received the solvent vehicle. Total RNA was extracted 24 hr post-injection and subjected to qPCR analysis. Values are given as relative units and presented as mean ± SD. *Significantly different from wt control, p < 0.05. **Significantly different from wt TCDD, p < 0.05, by two-tailed Student’s t-test.