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. 2015 Dec 18;124(7):1034–1041. doi: 10.1289/ehp.1510308

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Activation of IL-8 and cyclin D1: proposed POP mixture pathway shared by inflammation and cancer. Thick red and green arrows emphasize primary POP binding targets with inhibiting and activating effects, respectively. Yellow highlight indicates paths that needed an additional node (CREB1) to further converge on the same downstream targets via the PXR, whereas the AR and the AHR directly connected to the common downstream targets. AHR, aryl hydrocarbon receptor; PXR, pregnane X receptor. Symbols defined by MetaCore™ by Thomson Reuters http://lsresearch.thomsonreuters.com/static/uploads/files/2014-05/MetaCoreQuickReferenceGuide.pdf: green arrows, activating interactions; red arrows, inhibiting interactions; POPs (TCDD, PCB 153 and p,p´-DDE), purple hexagons, transcription factors, red symbols; cyclin D1, blue symbol; IL-8, green symbol.