Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Dec 11;124(7):1050–1061. doi: 10.1289/ehp.1510385

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.

PMC Copyright notice

In vivo phenotypic analysis: chemical coverage and workflow. (A) Experimental protocols in general follow EPA Health Effects Test Guidelines OPPTS ^a870.3700, ^b870.3100, 870.4100, 870.4200, 870.4300, ^c870.3800, and ^d870.3550. Test strains include ^eAlderly Park, CD, Fischer 344, Long-Evans, Sprague-Dawley, and Wistar for rats; ^fB6C3F1, CD, and Swiss for mice; and ^gChinchilla, Dutch, Himalayan, and New Zealand White for rabbits. The prenatal developmental study type (OPPTS 870.3700 or equivalent) consisted mostly of rabbit (527) and rat studies (731), whereas both one-generational and multigenerational reproductive study types (OPPTS 870.3800, 870.3550, or equivalent) consisted primarily of rat studies (104 and 455, respectively). The ToxRefDB subchronic and chronic study types (OPPT 870.3100, 870.4100, 870.4200, 870.4300, or equivalent) consisted mostly of mouse (568) and rat studies (984). (B) Workflow for data-mining ToxRefDB.