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. 2015 Dec 11;124(7):1050–1061. doi: 10.1289/ehp.1510385

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Unsupervised two-directional heatmap from hierarchical clustering of 212 male reproductive toxicants in ToxCastDB. Data for 212 male reproductive toxicants in ToxCastDB were used to construct a heat map to visualize the complex chemical–effects relationships on 213 molecular targets. The heat map was generated with the “gplot” package in R version 3.1.0, using Euclidean distance for measure and Ward’s method for linkage analysis. The intensity of blue color indicated the value of gene score.