Figure 1.
CD4+ T cells recognize distinct registers of the B:9–23 peptide. Response of the hybridomas IIT-3 (Left Panel) and 9B9 (Right Panel) to the Register 1, B:12–20 and the Register 2, B:13–21 peptides covalently linked to I-Ag7 expressed on C3.G7 cells. T cells directed to Register 1, B:12-20 escape negative selection and can enter islets.