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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Immunol Rev. 2016 Jul;272(1):183–201. doi: 10.1111/imr.12430

Figure 5.

Figure 5

Beta cells transfer immunogenic insulin to phagocytes. Left Panel: Graph shows the characterization of the two CD4+ T cells to insulin (1). The FLT-3L DCs were incubated with insulin or with the B:9–23 peptide, each at 10 μM. 8F10 reacts with peptides B:9–23 or B:12–20 (sequence shown below the graph) but not with insulin or B:13–21. IIT-3 reacts with insulin and peptides B:9–23 and B:13–21. Right Panel: A representative assay (of n > 25). Indicated are the cells used in the assay. Beta cells were from 6-wk-old NOD.Rag1−/− mice; the APCs were DCs obtained from the spleen of mice previously injected with FLT-3L. Background response of the T cells never exceeded 150 cpm. Adapted from reference 6.

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