Figure 3.

PIP₂- and ATP-binding sites of Kir6.2. Left. Structural model of Kir6.2 based on the X-ray structure of Kir2.2 [25]. The PI(4,5)P₂ molecule is positioned as in Kir2.2. A single subunit is shown in pink and the remaining three are blue. The membrane is shown in grey. The ATP is positioned based on the model by Antcliff et al. [26]. Right. A different view of the binding sites showing key PIP₂-binding residues (R176 and R177, [18]), and the slide helix.