Table 1. Comparison of overall median survivals according to strain, age and route.
Mice | Cells | Age | Route a | Cell No. | Cell form | Event b | Number of mice | Median survivals c |
---|---|---|---|---|---|---|---|---|
Balb/c-nu | 578T | 6 weeks | I.C. | 2×105 | w/ HBSS | Debility | 10 | 77 |
Balb/c-nu | 578T | 6 weeks | S.C. | 2×106 | w/ HBSS | Neoplasm | 10 | 80 |
NOD/SCID | 578T | 6 weeks | I.C. | 2×105 | w/ HBSS | Debility | 10 | 62 |
NOD/SCID | 578T | 6 weeks | S.C. | 2×106 | w/ HBSS | Neoplasm | 10 | 68 |
Neonate NOG | 578T | 1 week | I.C. | 2×105 | w/ HBSS | Debility | 10 | 45 |
Neonate NOG | 578T | 1 week | S.C. | 2×106 | w/ HBSS | Neoplasm | 10 | 54 |
Adult NOG | 578T | 6 weeks | I.C. | 2×105 | w/ HBSS | Debility | 10 | 60 |
Adult NOG | 578T | 6 weeks | S.C. | 2×106 | w/ HBSS | Neoplasm | 10 | 70 |
a. I.C.: Intracranial injection, S.C.: Subcutaneous injection
b. None: Not happened anything, Debility: decrease of weight and bad condition, Neoplasm: neoplasm into injection site
c. I.C. survivals: Condition and body weight, S.C. survivals: tumor volume ≥ 1,500 mm3