Table 3.
Genotype and allele frequencies of 5-HTR gene SNPs between responders/nonresponders and remissioners/nonremissioners
| Gene | SNP | Genotype frequency (%) | P-value Genotype | FDR adjusted | Allele frequency | P-value Genotype | SNP | Genotype frequency (%) | P-value Genotype | Allele frequency | P-value Genotype | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-HTR1A | rs1364043 | GG | GT | TT | 0.5352 | 0.84 | G | T | 0.8959 | rs1364043 | GG | GT | TT | 0.592 | G | T | 0.429 |
| Responders | 85 (38.64) |
103 (46.82) |
32 (14.54) |
273 (62.05) |
167 (37.95) |
Remissioner | 41 (34.17) |
62 (51.67) |
17 (14.17) |
144 (60) |
96 (40) |
||||||
| Nonresponders | 24 (34.29) |
38 (54.29) |
8 (11.42) |
86 (61.43) |
54 (38.57) |
Nonremissioner | 68 (40) |
79 (46.47) |
23 (13.53) |
215 (63.24) |
125 (36.76) |
||||||
| rs10042486 | TT | CT | CC | 0.0123 | 0.0615 | T | C | 0.544 | rs10042486 | TT | CT | CC | 0.441 | T | C | 0.293 | |
| Responders | 146 (66.36) |
58 (26.36) |
16 (7.27) |
350 (79.55) |
90 (20.45) |
Remissioner | 74 (61.67) |
36 (30) |
10 (8.37) |
184 (76.67) |
56 (23.33) |
||||||
| Nonresponders | 39 (55.71) |
30 (42.86) |
1 (1.43) |
108 (77.14) |
32 (22.86) |
Nonremissioner | 111 (65.29) |
51 (30) |
8 (4.71) |
273 (80.29) |
67 (19.71) |
||||||
| 5-HTR2A | rs6311 | TT | CT | CC | 0.9035 | 0.9035 | T | C | 0.7914 | rs6311 | TT | CT | CC | 0.909 | T | C | 0.676 |
| Responders | 79 (35.91) |
99 (45.0) |
42 (19.09) |
257 (58.41) |
183 (41.59) |
Remissioner | 42 (35) |
53 (44.17) |
25 (20.83) |
137 (57.08) |
103 (42.92) |
||||||
| Nonresponders | 25 (35.71) |
30 (42.86) |
15 (21.43) |
80 (57.14) |
60 (42.86) |
Nonremissioner | 62 (36.47) |
76 (44.71) |
32 (18.82) |
200 (58.82) |
140 (41.18) |
||||||
| rs6313 | TT | CT | CC | 0.4852 | 0.84 | T | C | 0.514 | rs6313 | TT | CT | CC | 0.983 | T | C | 0.986 | |
| Responders | 82 (37.27) |
98 (44.56) |
40 (18.18) |
262 (59.55) |
178 (40.45) |
Remissioner | 45 (37.5) |
51 (42.5) |
24 (20) |
141 (58.75) |
99 (41.25) |
||||||
| Nonresponders | 26 (37.14) |
27 (38.57) |
17 (24.29) |
79 (56.43) |
61 (43.57) |
Nonremissioner | 63 (37.06) |
74 (43.53) |
33 (19.41) |
200 (58.82) |
140 (41.18) |
||||||
| rs17289304 | TT | GT | GG | 0.672 | 0.84 | T | G | 0.6562 | rs17289304 | TT | GT | GG | 0.244 | T | G | 0.122 | |
| Responders | 200 (95.24) |
19 (4.28) |
1 (0.48) |
419 (95.23) |
21 (4.77) |
Remissioner | 105 (87.5) |
14 (11.67) |
1 (0.83) |
224 (93.33) |
16 (6.67) |
||||||
| Nonresponders | 62 (88.57) |
8 (11.43) |
0 (0) | 132 (61.21) |
8 (5.71) |
Nonremissioner | 157 (92.35) |
13 (7.65) |
0 (0) | 327 (96.18) |
13 (3.82) |
||||||
Abbreviations: FDR, False-discovery rate; SNP, single-nucleotide polymorphism.