Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jul 4;9:4061–4074. doi: 10.2147/OTT.S101423

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Xu et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

The pooled hazard ratio (HR) and 95% CI for survival following doublet agents therapy and single-agent therapy.

Notes: The size of the square box is proportional to the weight that each study contributes in the meta-analysis. The overall estimate and confidence interval are marked by a diamond. Symbols on the right of the solid line indicate HR >1, and symbols on the left of the solid line indicate HR <1. (A) Overall survival. (B) Progression free survival. For the subgroups, group 1 represents the studies that compared the two chemotherapy agents combination with single-agent therapy, and group 2 represents the studies that compared the targeted therapy plus chemotherapy with single-agent therapy. The HR and 95% CI for OS and PFS were calculated with a fixed effect model. Weights are from fixed effect model.

Abbreviations: CI, confidence interval; OS, overall survival; PFS, progression-free survival.