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. 2016 Jul 4;9:4061–4074. doi: 10.2147/OTT.S101423

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© 2016 Xu et al. This work is published and licensed by Dove Medical Press Limited

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Pooled risk ratio (RR) and 95% CI for frequently graded 3–4 toxicities following combination therapy and monotherapy.

Notes: The size of the square box is proportional to the weight that each study contributes in the meta-analysis. The overall estimate and confidence interval are marked by a diamond. Symbols on the right of the solid line indicate RR >1, and symbols on the left of the solid line indicate RR <1. (A) Anemia, (B) anorexia, (C) diarrhea, (D) leukopenia, (E) stomatitis, and (F) nausea. The RRs and 95% CIs of anemia, anorexia, and nausea were calculated with fixed effect models. And the RRs and 95% CIs of the other adverse effects were calculated with random effect models. Weights are from random effects analysis.

Abbreviation: CI, confidence interval.

Pooled risk ratio (RR) and 95% CI for frequently graded 3–4 toxicities following combination therapy and monotherapy.

Notes: The size of the square box is proportional to the weight that each study contributes in the meta-analysis. The overall estimate and confidence interval are marked by a diamond. Symbols on the right of the solid line indicate RR >1, and symbols on the left of the solid line indicate RR <1. (A) Anemia, (B) anorexia, (C) diarrhea, (D) leukopenia, (E) stomatitis, and (F) nausea. The RRs and 95% CIs of anemia, anorexia, and nausea were calculated with fixed effect models. And the RRs and 95% CIs of the other adverse effects were calculated with random effect models. Weights are from random effects analysis.

Abbreviation: CI, confidence interval.