Table 1.
Univariate analysis comparing cases of nodular and non-nodular Legionella pneumonia among patients undergoing treatment for cancer at MSKCC from 1999 to 2013.
| Nodular N = 8 (%) | Non-nodular N = 32 (%) | P value | |
|---|---|---|---|
| Demographics | |||
| Age in years (mean and range) | 44 (7–70) | 57 (9–73) | 0.17 |
| Male | 2 (25) | 20 (62) | 0.11 |
| Underlying malignancy | 0.03 | ||
| Solid tumor | 0 (0) | 14 (44) | |
| Hematologic/SCT | 8 (100) | 18 (56) | |
| Neutropenia (ANC <1000/mm3) | 0 (0) | 9 (28) | 0.16 |
| Legionella species | 0.06 | ||
| L. pneumophila | 4 (50) | 27 (84) | |
| Non-pneumophila | 4 (50) | 5 (16) | |
| Treatment | 1 | ||
| Quinolones | 5 (62.5) | 19 (60) | |
| Macrolides | 3 (37.5) | 10 (31) | |
| None | 0 | 3 (9) | |
| Symptoms (anya) | <0.001 | ||
| Asymptomatic | 4 (50) | 0 (0) | |
| Symptomatic | 4 (50) | 32 (100) | |
| Previous steroid use (within 30 days) | 2 (25) | 5 (16) | 0.61 |
SCT = stem cell transplant; ANC = absolute neutrophil count.
a
Including fever, cough, dyspnea, diarrhea, lethargy, headache, and change in mental status.