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. Author manuscript; available in PMC: 2017 Jan 20.
Published in final edited form as: Sci Transl Med. 2016 Jan 20;8(322):322ra10. doi: 10.1126/scitranslmed.aac7718

Figure 2. Systemic candidiasis results in increased mortality in Cxcr1−/− mice due to enhanced fungal proliferation in the kidney and renal failure.

Figure 2

(A) Schematic showing the generation of Cxcr1−/− mice by homologous recombination. (B) Mortality rates of Cxcr1+/+ and Cxcr1−/− mice after intravenous challenge with Candida (n=25; summary data of 3 independent experiments). P=0.015; Log-rank (Mantel-Cox) test. (C) Fungal burden in the kidneys of Cxcr1+/+ and Cxcr1−/− mice at days 4 (P=0.0135; n=14–15; 3 independent experiments; t-test with Welch’s correction) and 7 (P=0.025; n=30–31; 6 independent experiments; Mann-Whitney test) post-infection (D) Renal function is significantly compromised in Cxcr1−/− mice post-infection. Shown are summary data of serum BUN (P=0.0477; Mann-Whitney test) and creatinine (P=0.0403; Mann-Whitney test) at day 7 post-infection (n=17–18; 3 independent experiments). (E) Histopathology. Representative PAS staining of Cxcr1+/+ and Cxcr1−/− kidney sections at day 4 post-infection. Original magnification, 20x; Bar scale, 500 μm (n=15; 3 independent experiments). All quantitative data represent mean ± SEM.