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. Author manuscript; available in PMC: 2017 Jan 20.
Published in final edited form as: Sci Transl Med. 2016 Jan 20;8(322):322ra10. doi: 10.1126/scitranslmed.aac7718

Figure 4. Cxcr1 does not mediate neutrophil trafficking in the kidney during systemic candidiasis.

Figure 4

(A, B) Accumulation of neutrophils in Cxcr1+/+ and Cxcr1−/− kidneys at days 1, 4 and 7 post-infection. (A) Number of neutrophils. (B) Percent of neutrophils within total CD45+ leukocytes (n=6–15; 2–4 independent experiments). (C) Induction of neutrophil-targeted CXC chemokines in Cxcr1+/+ and Cxcr1−/− kidneys after Candida infection (n=6–8; 2 independent experiments). (D,E) Ratio of CD45.1+Cxcr1+/+ and CD45.2+Cxcr1−/− neutrophils in the blood before infection and in the blood and kidney at days 1 (D) and 4 (E) after Candida infection of mixed bone marrow radiation chimeras (n=6; 2 independent experiments). Data represent mean ± SEM.