Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Phenotype and viability of Tyr-edited embryos and mice by CRISPR-EZ
| Genome editing method | Embryos treated | Embryos transferred | Mice born | Coat color |
||
|---|---|---|---|---|---|---|
| Black | Albino | Mosaic | ||||
| mRNA injection | 136 (93)a | 60 | 5 | 1 (20%) | 3 (60%) | 1 (20%) |
| CRISPR-EZ, 1 ms | 140 | 85 | 44 | 23 (53%) | 12 (27%) | 9 (20%) |
| CRISPR-EZ, 3 ms | 120 | 90 | 33 | 1 (3%) | 29 (88%) | 3 (9%) |
a 93 of 136 collected embryos were injected after screening for presence of pronuclei. In contrast, CRISPR-EZ was performed on all collected embryos.
