TABLE 2.

Conferment of manganese and zinc resistance by hZnT10 or hZnT2 and their domain swapped/substituted mutants in SPCA1^−/−/− and ZnT1^−/−MT^−/−ZnT4^−/− cells

Relative values presented are evaluations of the results shown in Figs. 7 and 8, as described in Table 1.

Expressed gene	Manganese resistance in SPCA1−/−/− cells	Zinc resistance in ZnT1−/−MT−/−ZnT4−/− cells
hZnT10	+++	−a
hZnT2	−	+++
hZnT10(N43H)	−	−
hZnT2(H106N)	−	−
hZnT10(hZnT2Cter)	−	−
hZnT2(hZnT10Cter)	−	−a
hZnT10(N43H-hZnT2Loop-hZnT2Cter)	−	−
hZnT2(H106N-hZnT10Loop-hZnT10Cter)	−	−

^a A small fraction of the cells appeared morphologically normal by visual observation.