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. 2016 Jul 4;10:2137–2154. doi: 10.2147/DDDT.S108118

Table 4.

Summary of toxicity predictions for AfroCancer and NPACT datasets

Endpoints CERTAIN
PROBABLE
PLAUSIBLE
EQUIVOCAL
DOUBTED
AfroCancer NPACT AfroCancer NPACT AfroCancer NPACT AfroCancer NPACT AfroCancer NPACT
Carcinogenicity 1 17 107 71 134
Cardiotoxicity 1
Cholinesterase inhibition 1
Chromosome damage in vitro 2 4 16 113 503 9 132
Chromosome damage in vivo 6 6 11 1 18
Cyanide-type effects 1
Developmental toxicity 15 76
Genotoxicity in vitro 17 72
Hepatotoxicity 1 2 58 173
hERG channel inhibition in vitro 25 132
Irritation (of the eye) 17 133
Irritation (of the gastrointestinal tract) 27
Irritation (of the respiratory tract) 1 6
Irritation (of the skin) 17 133
Mutagenicity in vitro 18 70
Neurotoxicity 2
Ocular toxicity 2
Estrogenicity 9
Phospholipidosis 2
Photoallergenicity 40 77 2
Photocarcinogenicity 1 5 2
Phototoxicity 1 12 28
Rapid prototypes: bladder disorders 1 4
Rapid prototypes: cardiotoxicity 1
Rapid prototypes: chromosome damage in vitro 9
Rapid prototypes: hepatotoxicity 5 18 558
Rapid prototypes: mitochondrial dysfunction 25 56
Rapid prototypes: nephrotoxicity 131 546
Rapid prototypes: thyroid toxicity 6
Skin sensitization 6 3 564 1,568 64 190 208
Teratogenicity 2 5 13
Thyroid toxicity 8 52
Total 2 9 4 31 926 3,172 319 1,142 0 768

Abbreviation: NPACT, Naturally Occurring Plant-based Anticancer Compound-Activity-Target.