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. 2016 Mar 28;5(6):e1151593. doi: 10.1080/2162402X.2016.1151593

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — B16 cells expressing both NLRC5 and CD80 efficiently activate Pmel-1 CD8⁺ T cells. Naive and cytokine-primed Pmel-1 cells were co-cultured with irradiated (100Gy) B16-derived cell lines in the presence or absence of mgp100 peptide. Activation of Pmel-1 cells were evaluated after 3 d by analyzing (A) modulation of the expression of CD44 and CD62L, (B) production of IL-2, (C) expression of the effector cytokine TNFα and (D) mobilization of CD107b to the cell surface. Numbers within the histograms represent the percentage of cells within the quadrant or the indicated marker boundaries. Representative data from at least two experiments with similar results are shown.