Figure 1.

Neuroblastoma cells are sensitive to HDACi-mediated cell death. (A) TH-MYCN derived 9464D and 975A2 neuroblastoma cells, Neuro-2a neuroblastoma, GL261 glioblastoma and 3T3 fibrosarcoma cells were incubated for 36 h with 32, 256, 2048 and 16384 nM of the indicated HDACi. Following a 36 h incubation, standard MTT assays were performed, metabolic activity was compared to control treated cells and plotted in dose response curves (*p < 0.05 for 9464D or 975A2 vs. Neuro-2a or GL261 or 3T3). Representative graphs of three independent experiments are shown.