Figure 4.

I.t.-delivery of Rictor^−/− DC results in a therapeutic antitumor response in a contralateral tumor site. Mice bearing 7-d B16 tumors in each flank, with similar mean total tumor sizes, were injected with 50 µL of PBS or 50 µL of PBS containing 10⁶ control DC or 10⁶ Rictor^−/− DC on the right flanks. Tumors on the left flank of each animal were left untreated. Animals received an identical treatment on day 14 post-tumor implantation. Treated and untreated tumor sizes (in mm²) for each animal were then monitored longitudinally every 3–4 d, and are reported as means + SD for five animals per group. *p < 0.05.