CD137 signaling induces IL-13, TNF and IL-6 secretion by HRS cell lines. 5 × 105 L-428-control, L-1236-control, L-428-CD137, L-1236-CD137 or KM-H2 cells were cultured on plates coated with 5 μg/mL of recombinant CD137L or BSA for 24 h. Levels of IL-13 (A), TNF (B) and IL-6 (C) were measured by ELISA. Depicted are means ± SD of triplicate measurements. *p <0.05; **p <0.01; ***p <0.005. Data are representative of three independent experiments.