Figure 4.

Higher amounts of CD8⁺ lymphocytes within the invasive margin is associated with significantly longer disease free survival (DFS). Kaplan–Meier plots of disease free survival dichotomized at the respective CD8⁺ imTIL median of the primary tumor (also see Table 2) into CD8⁺ T cells high and CD8⁺ T cells low show that higher amounts of CD8⁺ T cells within the invasive margin of the primary tumor are generally (A) but also in the subgroups with distant metastasis into brain and bone except for soft tissue metastasis associated with a with significantly longer DFS again (B–D).