Table 2.
Distribution of tumor infiltrating lymphocytes (TIL) subsets within the primary tumor. Mean and median are displayed for CD4+, CD8+ and CD20+ lymphocytes within the three investigated primary tumor compartments consisting of intratumoral (iTIL), stromal (sTIL) and invasive margin (imTIL) TIL divided into the four anatomical sites (brain, bone, liver and soft tissue) of the corresponding metastasis.
| Site of Metastasis |
||||||||
|---|---|---|---|---|---|---|---|---|
| Brain (n = 21) |
Bone (n = 24) |
Liver (n = 11) |
Soft tissue (n = 31) |
|||||
| TIL within the primary tumor | Mean | Median | Mean | Median | Mean | Median | Mean | Median |
| iCD4+ T cells | 4.8 | 3.7 | 5.1 | 2.3 | 1.8 | .7 | 7.3 | 5.3 |
| iCD8+ T cells | 5.7 | 3.7 | 12.7 | 8.3 | 4.8 | 2.0 | 9.3 | 6.7 |
| iCD20+ B cells | 0.7 | 0.3 | 0.3 | 0.3 | 0.4 | 0.3 | 0.5 | 0.3 |
| sCD4+ T cells | 18.0 | 13.3 | 19.4 | 16.7 | 11.6 | 13.3 | 21.3 | 20.0 |
| sCD8+ T cells | 11.4 | 8.3 | 14.8 | 12.5 | 7.1 | 6.7 | 16.2 | 13.3 |
| sCD20+ B cells | 1.2 | 0.3 | 2.0 | 0.7 | 2.0 | 0.7 | 4.5 | 2.0 |
| imCD4+ T cells | 42.9 | 36.7 | 38.8 | 33.3 | 38.8 | 26.7 | 39.2 | 36.7 |
| imCD8+ T cells | 26.6 | 20.0 | 28.0 | 23.3 | 22.3 | 13.3 | 31.1 | 26.7 |
| imCD20+ B cells | 5.6 | 5.0 | 11.1 | 7.5 | 10.1 | 8.3 | 20.6 | 16.7 |