Table 10. Overview of HAMAP-Rule, Rule-Base, and SAAS.

System	Methodology	Evaluation methodology
HAMAP-Rule	Semi-automated/manual: rules are created by bio-curators and applied automatically	Bio-curator expertise:
Rule-Base	Semi-automated/manual: rules are created by bio-curators, statistically validated and applied automatically.	Bio-curator expertise + Each rule must have a confidence of more than 95%.
SAAS	Automated: rules are created by a C4.5 decision tree algorithm and applied automatically.	Each rule must have a confidence of more than 95%.