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. Author manuscript; available in PMC: 2016 Jul 8.
Published in final edited form as: Neurobiol Learn Mem. 2015 Sep 2;125:126–134. doi: 10.1016/j.nlm.2015.08.006

Fig. 6.

Fig. 6

Sustained phosphorylation of p70s6k is necessary for LTP in enriched animals. (A) The p70s6k inhibitor PF impairs LTP in enriched animals. (B) PF does not impact the synaptic response seen in SE animals. (C) OA enhances LTP in SE animals to levels similar to those seen in EE following 0.5 TBS. (D) OA does not enhance LTP in EE animals. (E) Western blot analysis reveals that p-p70s6k expression is significantly sustained 30 min following 0.5 TBS and that this expression is inhibited by rapamycin in EE rats. OA enhances p-p70s6k expression in SE rats. Results are quantified in panel F. Stim = 0.5 TBS. NS = non-stimulated slices.