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. 2016 Jul 8;12(7):e1006137. doi: 10.1371/journal.pgen.1006137

Fig 5. Candidate causal regulators of the Blue-mmSS module are upstream of HD-relevant nodes.

Fig 5

(A) Bayesian network reconstruction of the Blue-mmSS reveals 26 CCRs (large labeled nodes). (B) Genes in Thistle2-hsHD, especially those with FOXO3 binding sites, are significantly overrepresented in the Blue-mmSS downstream network. Significance threshold (red line): P = 0.01, two-sided. (C) Enrichment of the causal regulator PIN for huntingtin protein binding partners identified by affinity purification-mass spectrometry (AP-MS) and yeast two-hybrid (Y2H) methods, and for genes necessary for voluntary movement and affective behavior. Significance thresholds (red line): P = 0.01, two-sided; Odds Ratio (95% Confidence Interval) = 2. (D) Drugs that concordantly upregulate (Drug-Causal Regulator Association Score > 0) and downregulate (Drug-Causal Reulgator Association Score < 0) Blue-mmSS CCRs. All drugs shown have Benjamini-Hochberg adjusted P < 0.05.