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. 2016 Jul 8;11(7):e0158594. doi: 10.1371/journal.pone.0158594

Fig 3. Intrinsic disorder according to transmembrane protein classes and topology.

Fig 3

(A) Organization of the different protein dataset depending on the transmembrane protein classes and the presence or not of IDRs. B) Percent of IDRs localized in the cytoplasm or the extracellular domain of single-pass and multi-pass proteins. (C) Prediction of MoRFs in the proteins from the fully folded protein (FOP) and IDP datasets. Mann-Whitney Significance test ***: p value < 0.0001. (D) Percentage of MoRFs localized either on the cytoplasmic or extracellular part of transmembrane proteins. (E) BMPR2 (UniProtID: Q13873) is a single-pass transmembrane protein with a long predicted IDR in the cytoplasmic side. The red boxes show the position of the MoRFs detected in BMPR2. (F) zDHHC8 (UniProtID: Q9ULC8) is a multi-pass transmembrane protein with a long predicted IDR in the cytoplasmic side. For (C) and (D), the blue dots represent the average disorder score using PONDR-FIT, IUPRED and DISOPRED2 prediction tools and the error bars the standard error. The blue lane shows the position of the transmembrane domain and the grey area the cytoplasmic C-terminal part of the protein.